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Market Cap 3.77B P/E - EPS this Y -138.70% Ern Qtrly Grth -
Income -419.65M Forward P/E -8.01 EPS next Y -5.90% 50D Avg Chg -8.00%
Sales 1.27M PEG - EPS past 5Y - 200D Avg Chg -3.00%
Dividend N/A Price/Book 3.90 EPS next 5Y - 52W High Chg -30.00%
Recommedations 1.70 Quick Ratio 12.04 Shares Outstanding 143.16M 52W Low Chg 27.00%
Insider Own 13.61% ROA -22.04% Shares Float 123.73M Beta 1.37
Inst Own 90.45% ROE -32.61% Shares Shorted/Prior 9.40M/8.36M Price 27.56
Gross Margin - Profit Margin - Avg. Volume 688,159 Target Price 40.00
Oper. Margin -39,085.40% Earnings Date Nov 5 Volume 498,608 Change -2.68%
About Denali Therapeutics Inc.

Denali Therapeutics Inc., a biopharmaceutical company, develops a portfolio of product candidates engineered to cross the blood-brain barrier for neurodegenerative diseases and lysosomal storage diseases in the United States. The company's transport vehicle (TV)-enabled programs include DNL310 ETV, an IDS enzyme replacement therapy program for MPS II; TAK-594/DNL593 which is in Phase 1/II for frontotemporal dementia-granulin; DNL126 program for MPS IIIA; and DNL622 for MPS I, as well as other preclinical programs that target amyloid beta and HER2. Its brain-penetrant small molecule programs comprise BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; SAR443820/DNL788 RIPK1 inhibitor program for CNS disease; DNL343 eIF2B Activator program for amyotrophic lateral sclerosis; and SAR443122/DNL758 RIPK1 inhibitor program for peripheral inflammatory diseases. It also provides early stage program include TAK-594/DNL593 program for FTD-GRN; DNL126 program for MPS IIIA, a Sanfilippo Syndrome A; DNL622 for MPS I which is Hurler syndrome; Antibody Transport Vehicle Amyloid beta program; Oligonucleotide Transport Vehicle platform, a novel class of biotherapeutics to address the root cause of diseases through modulation of gene expression; and other TV-enabled discovery programs. The company has collaboration agreements with Biogen MA Inc. and Biogen International GmbH; Genzyme Corporation; Takeda Pharmaceutical Company Limited; F-star Gamma Limited, F-star Biotechnologische Forschungs-und Entwicklungsges m.b.H, and F-star Biotechnology Limited; and Genentech, Inc. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Denali Therapeutics Inc. News
11/15/24 We're Hopeful That Denali Therapeutics (NASDAQ:DNLI) Will Use Its Cash Wisely
11/08/24 Denali Q3 Earnings Miss Estimates, Pipeline Progress Encouraging
11/06/24 Denali Therapeutics Reports Third Quarter 2024 Financial Results and Business Highlights
10/30/24 Analysts Estimate Arcus Biosciences, Inc. (RCUS) to Report a Decline in Earnings: What to Look Out for
10/29/24 Denali Therapeutics Inc. (DNLI) May Report Negative Earnings: Know the Trend Ahead of Q3 Release
10/13/24 Denali Therapeutics Inc. (DNLI): Jeff Bezos Is Buying This Stock Now
10/07/24 Strength Seen in Voyager Therapeutics (VYGR): Can Its 17.5% Jump Turn into More Strength?
09/16/24 Strength Seen in Denali Therapeutics (DNLI): Can Its 10.1% Jump Turn into More Strength?
09/06/24 Why Is Kymera Therapeutics (KYMR) Up 10.9% Since Last Earnings Report?
09/05/24 Myriad (MYGN) Down 4.8% Since Last Earnings Report: Can It Rebound?
09/04/24 Denali Plans to File for Accelerated Approval of Hunter Syndrome Drug
09/04/24 Why Is BioMarin (BMRN) Up 5.4% Since Last Earnings Report?
09/04/24 High-dose Spinraza meets study goal; Top Dyne executives exit
09/03/24 Denali Therapeutics Announces Successful Meeting with the FDA and Plans to File for Accelerated Approval of Tividenofusp Alfa (DNL310) for the Treatment of MPS II (Hunter Syndrome)
08/26/24 Denali Therapeutics (NASDAQ:DNLI) shareholders are up 3.4% this past week, but still in the red over the last three years
08/19/24 Genetic testing in Parkinson’s disease patients: a standard of care imperative?
08/14/24 Denali Therapeutics Announces Publication in Science Translational Medicine Demonstrating the Potential of the Oligonucleotide Transport Vehicle Platform to Achieve Broad Biodistribution of Antisense Oligonucleotides in the CNS and Muscle Following Intravenous Administration
08/06/24 Wall Street Analysts Believe Denali Therapeutics (DNLI) Could Rally 79.62%: Here's is How to Trade
08/01/24 Denali Therapeutics Reports Second Quarter 2024 Financial Results and Business Highlights
07/23/24 Denali Therapeutics (DNLI) Stock Jumps 9.7%: Will It Continue to Soar?
DNLI Chatroom

User Image DonCorleone77 Posted - 2 weeks ago

$DNLI Denali Therapeutics sees Fy24 opex increase of 5%-10% year-over-year Denali is providing updated guidance on cash operating expenses for FY24 and now anticipates an increase of approximately 5%-10% compared to 2023, which is an increase from previous guidance of equal to or less than FY23 cash operating expenses. This updated guidance is associated with increased activities to support filing of a BLA in early 2025 and commercial readiness for tividenofusp alfa in MPS II, and to accelerate the development of additional therapeutic programs in Denali's TV platform portfolio.

User Image DonCorleone77 Posted - 2 weeks ago

$DNLI Denali Therapeutics reports Q3 EPS (63c), consensus (61c) There was no collaboration revenue for Q3, compared to $1.3M for Q3 of 2023. The decrease in collaboration revenue was primarily due to activities under the Biogen Collaboration Agreement. Cash, cash equivalents, and marketable securities were approximately $1.28B as of September 30, 2024.

User Image RallyRaider Posted - 10/28/24

$DNLI nice chart play to 31$

User Image Estimize Posted - 10/28/24

Estimize revenue expectations are 100.00% lower than that of Wall Street for $DNLI Q3 [Reporting 10/31 BMO] http://www.estimize.com/intro/d

User Image insiderbuyingselling Posted - 10/23/24

$DNLI new insider selling: 40000 shares. http://insiderbuyingselling.com/?t=DNLI

User Image net0trader Posted - 1 month ago

$DNLI good pullback and nice hold at that 26 level. Liking the price action here, giving a good risk reward entry here.

User Image briefingcom Posted - 1 month ago

$DNLI: Denali Therapeutics was informed by its strategic partner Sanofi (SNY) that the K2 Phase 2 study evaluating the safety and efficacy of oditrasertib (SAR443820/DNL788) on serum neurofilament light chain levels in participants with multiple sclerosis was discontinued based on not meeting the primary and key secondary endpoints

User Image Benzinga Posted - 1 month ago

Denali Therapeutics Stock Is Sliding After The Bell: Here's Why https://www.benzinga.com/general/biotech/24/10/41282170/denali-therapeutics-stock-is-sliding-after-the-bell-heres-why $DNLI

User Image Shlobby Posted - 1 month ago

$DNLI need an sos green candle here

User Image vjtweet Posted - 09/27/24

$DNLI bought some with tight stop.

User Image BobBijawklah Posted - 09/25/24

$IBRX Another possible clinical partnership should be looked into with $dnli utilizing their delivery system that is able to pass through the blood brain barrier. Maybe something in gioblastoma with one of our Hank vaccines or possibly anktiva.

User Image vjtweet Posted - 09/24/24

$DNLI I will wait for decent entry points around 28.

User Image CrazyCoolMedallions Posted - 2 months ago

$DNLI Does anyone know when Denali’s Phase II/III DNL343 Regimen G HEALEY ALS Platform Trial is slated to end? Is it December 2024?

User Image Laynester Posted - 2 months ago

$DNLI We were alerted to DNLI a few days ago...based on long term trends, glad we bought in this morning at $26.40 at that time (see the daily graph). Now it's $31.90 (up 16%). Truly luck based on hard researched long term trends lines. We have a 7% trlr stop set - will drop that to 3.5% when one of our leading l-t indicators shows weakness. DLNI investors knew this was a winner.

User Image Shlobby Posted - 2 months ago

Time to climb a big mtn in $DNLI

User Image Tomppa Posted - 2 months ago

$DNLI I lost my nerves with all these new highs and those scary news that owners has been selling, I have seen too many times what happens when owners sells to up trend, even if it should not mean anything 😅

User Image Shlobby Posted - 2 months ago

$DNLI entered few days ago looking promising

User Image net0trader Posted - 2 months ago

@MaverikIT @IsabellaDC $DNLI still going… and volume coming in. Looking good for a big move

User Image Tomppa Posted - 2 months ago

$DNLI here we are, 52w highs in a strange day, wish I would own a lot more of this 😃

User Image net0trader Posted - 2 months ago

@MaverikIT @IsabellaDC $DNLI holding strong. Nice base here. @RonIsWrong you in this one?

User Image GakiYoui_Atsu Posted - 2 months ago

WIMI Hologram Cloud( $WIMI) had its price objective from Evaluate Research, $5.00 Average Target Price from Evaluate Research Lattice Semiconductor Co. ($LSCC) Receives $65.17 Average Target Price from Brokerages Analysts Set Denali Therapeutics Inc. ($DNLI) Target Price at $38.33 Comstock Resources, Inc. ($CRK) Receives $9.75 Average Target Price from Brokerages Brokerages Set IDEAYA Biosciences, Inc. ($IDYA) Target Price at $55.70

User Image MysticChartReaderIQ69 Posted - 2 months ago

$DNLI was hoping for a dip today to get my nibble on but nice resistance to the market

User Image MaverikIT Posted - 2 months ago

@net0trader @IsabellaDC $SEZL ing $SNCR - steady $DNLI

User Image Stock_Titan Posted - 2 months ago

$DNLI Denali Therapeutics Announces Successful Meeting with the FDA and Plans to File for Accelerated Approval of Tividenofusp Alfa (DNL310) for the Treatment of MPS II (Hunter Syndrome) https://www.stocktitan.net/news/DNLI/denali-therapeutics-announces-successful-meeting-with-the-fda-and-e1czb5fxcy8n.html

User Image MaverikIT Posted - 08/26/24

@IsabellaDC @net0trader $DNLI - new 52wk$ hi @rxptgh

User Image MaverikIT Posted - 08/26/24

@IsabellaDC @net0trader @RonIsWrong $GLPG - damn this once 200'$ $SWTX $KYMR $VKTX $DNLI ...

User Image Tomppa Posted - 08/26/24

$DNLI all time high, nice to see you

User Image MaverikIT Posted - 3 months ago

@rxptgh $DNLI - that segment (neurodegenerative diseases) been quietly marching on

User Image MaverikIT Posted - 3 months ago

$DNLI +1.35 - knocking on 52wk$ hi

User Image MaverikIT Posted - 3 months ago

@IsabellaDC @net0trader @DonCorleone77 @CycleTrade @RonIsWrong @Cash4freedom @Im_not_Mr_Lebowski $DNLI +1.19

Analyst Ratings
Cantor Fitzgerald Overweight Sep 9, 24
HC Wainwright & Co. Buy Sep 4, 24
B of A Securities Buy Sep 4, 24
HC Wainwright & Co. Buy Aug 15, 24
HC Wainwright & Co. Buy Aug 5, 24
Citigroup Buy Aug 2, 24
Wedbush Outperform Aug 2, 24
JP Morgan Overweight Jul 10, 24
Wedbush Outperform May 8, 24
Insider Trades Relationship Date Transactions Cost($) #Shares Value($) #Share Own SEC Form 4
SATO VICKI L Director Director Jan 16 Sell 18.42 1,666 30,688 123,041 01/18/24
Ho Carole Chief Medical Office.. Chief Medical Officer Jan 10 Sell 19.02 4,668 88,785 147,794 01/12/24
Watts Ryan J. President and CEO President and CEO Jan 09 Sell 19.78 7,818 154,640 2,268,363 01/11/24
Ho Carole Chief Medical Office.. Chief Medical Officer Jan 05 Sell 19.43 9,972 193,756 198,777 01/09/24
Krognes Steve E. Director Director Jan 05 Sell 19.43 3,208 62,331 142,591 01/09/24
Schuth Alexander O. COFO and Secretary COFO and Secretary Jan 05 Sell 19.43 9,972 193,756 539,307 01/09/24
Watts Ryan J. President and CEO President and CEO Jan 05 Sell 19.43 17,483 339,695 2,276,181 01/09/24
SATO VICKI L Director Director Dec 15 Sell 23.39 1,666 38,968 124,707 12/18/23
SATO VICKI L Director Director Nov 15 Sell 19.13 1,666 31,871 126,373 11/16/23
SATO VICKI L Director Director Oct 16 Sell 20.66 1,666 34,420 128,039 10/18/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Aug 23 Sell 23.17 2,522 58,435 518,989 08/25/23
Ho Carole Chief Medical Office.. Chief Medical Officer Aug 23 Sell 23.22 2,522 58,561 182,809 08/25/23
Krognes Steve E. Director Director Aug 21 Sell 22.60 1,419 32,069 145,799 08/23/23
SATO VICKI L Director Director Aug 15 Sell 24.30 1,666 40,484 131,371 08/17/23
Ho Carole Chief Medical Office.. Chief Medical Officer Aug 14 Sell 23.79 2,768 65,851 182,809 08/16/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Aug 14 Sell 23.67 2,772 65,613 518,989 08/16/23
Watts Ryan J. President and CEO President and CEO Aug 10 Sell 25.03 2,526 63,226 2,239,913 08/14/23
Watts Ryan J. President and CEO President and CEO Aug 10 Option 0.68 2,526 1,718 2,242,439 08/14/23
Ho Carole Chief Medical Office.. Chief Medical Officer Aug 10 Sell 24.15 2,857 68,997 185,577 08/14/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Aug 10 Sell 24.18 2,853 68,986 521,761 08/14/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Jul 17 Sell 29.81 19,702 587,317 518,989 07/19/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Jul 17 Option 5.28 10,000 52,800 538,691 07/19/23
SATO VICKI L Director Director Jul 17 Sell 29.60 1,666 49,314 133,037 07/19/23
SATO VICKI L Director Director Jun 28 Sell 29.77 1,666 49,597 134,703 06/30/23
Watts Ryan J. President and CEO President and CEO Apr 20 Option 0.68 25,000 17,000 2,264,713 04/24/23
Watts Ryan J. President and CEO President and CEO Apr 20 Sell 25.08 25,000 627,000 2,239,913 04/24/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Apr 12 Sell 25.04 10,000 250,400 528,691 04/14/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Apr 12 Option 5.28 10,000 52,800 533,589 04/14/23
Krognes Steve E. Director Director Feb 13 Sell 30.10 2,119 63,782 143,002 02/15/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Feb 13 Sell 30.09 3,497 105,225 528,691 02/15/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Feb 13 Option 0.68 25,000 17,000 524,902 02/15/23
Watts Ryan J. President and CEO President and CEO Feb 13 Sell 30.09 33,815 1,017,493 2,239,913 02/15/23
Watts Ryan J. President and CEO President and CEO Feb 13 Option 0.68 25,000 17,000 2,264,913 02/15/23
Ho Carole Chief Medical Office.. Chief Medical Officer Feb 10 Sell 29.95 3,366 100,812 184,285 02/14/23
Watts Ryan J. President and CEO President and CEO Feb 09 Sell 29.85 28,433 848,725 2,229,031 02/13/23
Watts Ryan J. President and CEO President and CEO Feb 09 Option 0.68 25,000 17,000 2,254,031 02/13/23
Ho Carole Chief Medical Office.. Chief Medical Officer Jan 05 Sell 28.56 4,087 116,725 178,913 01/09/23
Krognes Steve E. Director Director Jan 05 Sell 28.44 2,970 84,467 146,498 01/09/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Jan 05 Sell 28.44 2,636 74,968 497,173 01/09/23
Watts Ryan J. President and CEO President and CEO Jan 05 Sell 28.44 4,800 136,512 2,223,664 01/09/23
Ho Carole Chief Medical Office.. Chief Medical Officer Jan 03 Sell 28.69 2,913 83,574 175,500 01/05/23
Schuth Alexander O. COFO and Secretary COFO and Secretary Jan 03 Sell 28.7 2,912 83,574 149,828 01/05/23
Watts Ryan J. President and CEO President and CEO Jan 03 Sell 28.73 5,029 144,483 2,213,464 01/05/23
Tessier-Lavigne Marc Director Director Nov 23 Sell 30.48 20,000 609,600 1,870,356 11/28/22
Tessier-Lavigne Marc Director Director Sep 28 Sell 30.91 20,000 618,200 1,910,356 09/30/22
Tessier-Lavigne Marc Director Director Aug 23 Sell 32.02 20,000 640,400 1,930,356 08/25/22
Ho Carole Chief Medical Office.. Chief Medical Officer Aug 23 Sell 31.98 2,424 77,520 170,663 08/25/22
Watts Ryan J. President and CEO President and CEO Aug 19 Sell 33.22 2,404 79,861 2,202,993 08/23/22
Krognes Steve E. Director Director Aug 19 Sell 33.22 2,253 74,845 149,468 08/23/22
Schuth Alexander O. COFO and Secretary COFO and Secretary Aug 19 Sell 33.22 2,576 85,575 467,471 08/23/22