ntlaguy
Posted - 24 minutes ago
Here are the top late-stage drugs in Regeneron’s Phase 3 pipeline, focusing on new drugs that have not been approved for any prior indications. This breakdown highlights their projected annual revenues and their potential impact on the company's future growth.
1. Nexiguran Ziclumeran (NTLA-2001) • Indications: Transthyretin Amyloidosis with Cardiomyopathy (ATTR-CM) and Polyneuropathy (ATTR-PN) • Target: TTR gene knockout using CRISPR/Cas9 • Details: The first in vivo CRISPR-based therapy offering a potentially curative one-time treatment for ATTR amyloidosis. • Projected Annual Revenue: $1 billion+ from ATTR-PN alone, with a multibillion-dollar market opportunityif successful in ATTR-CM, which affects a much larger population. Split 75% $NTLA and 25% $REGN
2. Itepekimab (in collaboration with Sanofi) • Indication: Chronic Obstructive Pulmonary Disease (COPD) • Target: IL-33 • Details: A monoclonal antibody targeting airway inflammation, aiming to address an unmet need in COPD treatment. • Projected Annual Revenue: Estimated at $1.5 billion, leveraging the significant COPD patient population and demand for new therapies.
3. Odronextamab • Indications: Follicular Lymphoma (FL) and Diffuse Large B-Cell Lymphoma (DLBCL) • Target: CD20 and CD3 • Details: A bispecific antibody designed to engage T-cells to destroy B-cell malignancies. • Projected Annual Revenue: $800 million by 2035, addressing relapsed or refractory B-cell lymphomas.
4. Linvoseltamab • Indication: Multiple Myeloma • Target: BCMA and CD3 • Details: A bispecific antibody targeting myeloma cells, aiming to improve survival rates in patients with multiple myeloma. • Projected Annual Revenue: Estimated at $500 million, depending on market competition and uptake.
5. Fianlimab • Indications: First-line Metastatic Melanoma and Adjuvant Melanoma • Target: LAG-3 • Details: A monoclonal antibody offering an alternative checkpoint inhibition strategy to expand melanoma treatment options. • Projected Annual Revenue: Approximately $400 million, reflecting competition in the melanoma immunotherapy space.
6. Pozelimab (REGN3918) • Indications: Myasthenia Gravis, Paroxysmal Nocturnal Hemoglobinuria (PNH), Geographic Atrophy (all in combination with Cemdisiran) • Target: C5 • Details: A monoclonal antibody addressing complement-mediated disorders in combination therapies. • Projected Annual Revenue: $300 million, with potential growth across multiple indications.
7. Garetosmab • Indication: Fibrodysplasia Ossificans Progressiva (FOP) • Target: Activin A • Details: A first-in-class therapy for a rare and debilitating genetic disorder with no current treatments. • Projected Annual Revenue: Estimated at $100 million, given the small FOP patient population.
8. REGN5713-5714-5715 • Indication: Birch Allergy • Target: Bet v 1 • Details: A monoclonal antibody combination for severe birch pollen allergies. • Projected Annual Revenue: Approximately $50 million, reflecting its niche market size.
PencilNeckGeek
Posted - 3 hours ago
$REGN good risk / reward here at this level imo
ntlaguy
Posted - 4 hours ago
$REGN $NTLA
ntlaguy
Posted - 4 hours ago
$REGN $NTLA This.
diamondoptionsinc
Posted - 5 hours ago
$REGN really might go full circle and trade at $700 again 😅
jeffmeredith
Posted - 7 hours ago
$REGN I check each day for a curl and the curl never comes. Any index deterioration and $700 comes fast. They really beat the crap out of this.
LadyBoyStonks
Posted - 7 hours ago
$REGN it closed already, which is why I bought it at $740, the open price that day, and why I went long today bc that gap down getting closed, it could get worse though, sept 7 2023, gap at 599, which is where it may head unfortunately, we shall see soon enough
momobull
Posted - 7 hours ago
$regn omg, I see it now. They want to close the 732 gap left open on Aug 2 2023.
momobull
Posted - 8 hours ago
$REGN unprecedented, I cannot find a comparable stock being buried coming off all time highs at this low of an RSI reading between 12-15 for 17 trading days. One idiot gave me meta and nflx, 🤡 not even speaking the same language.
momobull
Posted - 8 hours ago
$regn holy sheet, get your act together Stocktwits. Scared the f out of me
Khanvict27
Posted - 8 hours ago
$REGN I have soo many cuts from trying to catch this knife. This shitty stock owes me $7k
Whiskeyunderthebed
Posted - 8 hours ago
$REGN this is a solid buy here. This has been getting accumulated for the last 10 trading days
Sebast_Texas
Posted - 8 hours ago
$REGN There had been lots of dark pool moves this week. In my opinion big whales covering already. Next week could reverse hard. Could run to test the sma10 around 775. My two cents. Unless Russia sents another interxontinental missile to Ukraine and market goes to shit.
seet79
Posted - 8 hours ago
$REGN CEO needs to go - 50% haircut within a few months/-/
momobull
Posted - 10 hours ago
$regn 12-15 RSI since Nov1st. I've never seen it on a large cap like this for that long a period. NEVER!
kenbkb
Posted - 10 hours ago
$REGN I added 6 times on different days on the way down from 820. Never would have believed this would happen to such a revered co as REGN. I have to hearken back to a quote from Peter Lynch years ago... NEVER THINK A STOCK CANNOT GO LOWER, CAUSE IT CAN.
momobull
Posted - 10 hours ago
$REGN i said buckle up to go up not down. POS
Fitz54
Posted - 10 hours ago
$REGN better hold the 52 week low or this is gonna be ugly
shawnv069
Posted - 10 hours ago
$REGN puts?
LadyBoyStonks
Posted - 11 hours ago
$REGN they want every inch of it lmao Jesus😂
LadyBoyStonks
Posted - 11 hours ago
$REGN touch some grass bro or cash out, u clearly too over leveraged spam raging the board like this lol
momobull
Posted - 11 hours ago
$REGN I've never been so frustrated in my life with a reputable name. unbelievable, this garbage
momobull
Posted - 12 hours ago
$regn here we go, buckle up!
momobull
Posted - 12 hours ago
$REGN hot steaming garbage
forprofit12
Posted - 14 hours ago
$REGN sorry not up to date on this one. What happened? This was always so promising?
momobull
Posted - 14 hours ago
$mrk and $mrna fully recovered from RFK drop. $regn this stinking poop still at dirt bottom.
Fitz54
Posted - 14 hours ago
$REGN nope lol
EthanJenkins1
Posted - 15 hours ago
$BMY $MRK $PFE $REGN $CKPT: Regarding CKPT ($3.50). I thought I would tag the other boards since this information will directly impact their share price. CKPT is obviously on the brink of a major FDA approval that could seriously cut into these other companies revenue, but according to ChatGPT, one of these companies will probably acquire CKPT very soon, in which case their shareholders should still know so they can have the opportunity to buy CKPT now before it happens.
Fitz54
Posted - 15 hours ago
$REGN be great if this could find support at 750
momobull
Posted - 15 hours ago
$mrna huge runner. $pfe even this bouncing. $mrk also $regn pile of trash after getting clobbered 40% in 2.5 months. NOTHING